Quantitative Structure ‒ Antiprotozoal Activity Relationships of Sesquiterpene Lactones
نویسندگان
چکیده
منابع مشابه
Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones.
Prompted by results of our previous studies where we found high activity of some sesquiterpene lactones (STLs) against Trypanosoma brucei rhodesiense (which causes East African sleeping sickness), we have now conducted a structure-(in-vitro)-activity study on a set of 40 STLs against T. brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. Furthermore, cytotoxic activity ...
متن کاملHologram QSAR studies of antiprotozoal activities of sesquiterpene lactones.
Infectious diseases such as trypanosomiasis and leishmaniasis are considered neglected tropical diseases due the lack for many years of research and development into new drug treatments besides the high incidence of mortality and the lack of current safe and effective drug therapies. Natural products such as sesquiterpene lactones have shown activity against T. brucei and L. donovani, the paras...
متن کاملSesquiterpene Lactones from Achillea
The species of genus Achillea, particularly those belonging to the Achillea millefolium group have received a lot of attention so far, due to their use in traditional medicine. Among the numerous chemical compounds isolated from the A. millefolium species, the sesquiterpene lactones are usually one of the major constituents (Seaman, 1982). Continuing our chemotaxonomic examination of Bulgarian ...
متن کاملAntitumoral activity of new pyrimidine derivatives of sesquiterpene lactones.
Sesquiterpene lactones display a wide variety of biological effects such as antiviral, anti-inflammatory and cytotoxic activity. In previous studies some derivatives of sesquiterpene lactones were prepared to be tested as antiviral and/or cytoxic agents. In the present report we describe the effects of seven modified sesquiterpene lactones on the proliferation of several cancer cell lines. We d...
متن کاملCitotoxic Activity of Extracts and Sesquiterpene Lactones from Stachycephalum argentinum
The extracts and sesquiterpene lactones of S.argentinum were assayed to determine their biological activity on Artemia salina. The most active compound was costunolide (1) with LD50= 62 ppm. Introduction Our previous phytochemical study of Stachychephalum argentinum (Asteraceae), revelead the presence of several skeletal types sesquiterpene lactones [1]. In order to explore new natural bioactiv...
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ژورنال
عنوان ژورنال: Molecules
سال: 2009
ISSN: 1420-3049
DOI: 10.3390/molecules14062062